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Team

Petra Kluger

Prof. Dr. Petra Kluger

Sprechstunde während der Vorlesungszeit:

nach Vereinbarung

Building 2
Room 118
Phone +49 07121 271-2061
Send e-mail »

Teaching areas

Vorlesungen:

  • Humanbiologie
  • Praktikum Chemische Grundlagen der Biomedizin
  • Wissenschaftliches Arbeiten und Grundlagen der Biomedizin
  • Tissue Engineering
  • Immunologie
  • Biofabrication & Regenerative Medicine

Schwerpunkte:

  • Tissue Engineering
  • Zellmaterial-Interaktionen / Cell-material interaction
  • Biomaterialien, Oberflächenmodifikation / Biomaterials, surface modification
  • Zellbasierte in-vitro Testsysteme / Cell-based in vitro assays
Publications

Ausgewählte Publikationen finden Sie hier.

Vita

Professional experience

01/2019 - 12/2028

Association at the faculty of Natural Sciences at the University of Hohenheim, Germany with the right to award doctorates (Dr. rer. nat.)

Since 09/2018 

Vice-president at Reutlingen University, Germany

Since 11/2017

Full Professor (W3) for Tissue Engineering and Biofabrication at Reutlingen University, Germany

11/2013 – 10/2017 

Shared-Professor (W3) for Tissue Engineering (49%) at Reutlingen University, Germany

05/2013 – 10/2017

Head of the Department Cell and Tissue Engineering (51%) at the Fraunhofer Institute for Interfacial Engineering and Biotechnology (IGB) in Stuttgart, Germany

05/2009 – 04/2012

Deputy Head of the Department Cell and Tissue Engineering and group leader at the Fraunhofer Institute for Interfacial Engineering and Biotechnology (IGB) in Stuttgart, Germany

Education and Training

08/2016 – 09/2016

DAAD Short-term lectureship (Stipend) for teaching Biofabrication at Worcester Polytechnic Institute in Massachusetts, USA)

10/2010 – 10/2011 

Baden-Württemberg Certificate for University Didactic 150 h advanced training in various aspects of didactic

07/2009

Doctoral Examination passed with “summa cum laude” at the University of Stuttgart, Germany

05/2006 – 04/2009 

PhD-stipend from the Peter and Traudl Engelhorn foundation

11/2007 – 11/2008

Postgraduate distance study on Nanobiotechnology at the University of Kaiserslautern; final grade: “good“

10/2000 – 04/2006

Studies of Technical Biology at the University of Stuttgart, final grade: “excellent“

Sonstige Funktionen

  • Vice President Forschung
  • Prüfungsausschuss Bachelor Biomedizinische Wissenschaften
  • Prüfungsausschuss Master Biomedical Sciences
  • Mitglied der Studienkommission
  • Leitung des Arbeitskreises "Tissue Engineering" im Fachausschuss Biomaterialien, Deutsche Gesellschaft für Materialkunde (DGM)

 

Franziska Albrecht

M.Sc. Franziska Albrecht

Thematische Schwerpunkte:

  • 3D Hydrogele
  • Biomaterialien
  • Zell-Material-Interaktion
  • Bioprinting
  • Humanes Fettgewebe

Building 2
Room 008
Phone +49 07121 271-1462
Send e-mail »

Publications

Completely defined co-culture of adipogenic differentiated adipose-derived stem cells and microvascular endothelial cells
Ann-Cathrin Volz, Larissa Hack, Franziska Atzinger, Petra J. Kluger
ALTEX (2018) 35(4):464-476

Vita

2019 – heute

Promotion: Ernährungswissenschaften, Universität Hohenheim
Thema: Entwicklung und Testung eines mittels Bioprinting gefertigten, in vivo nahen 3D Fettgewebemodells basierend auf primären Zellen der humanen Subkutis

2017 – 2019

Master: Biomedical Sciences (Schwerpunkt Physiologie), Hochschule Reutlingen
Thema: Establishment of an extrusion-based bioprinting process and GelMA bioink adaptation for the setup of 3D fatty tissue constructs

2014 – 2017

Bachelor: Biomedizinische Wissenschaften, Hochschule Reutlingen
Thema: Entwicklung eines chemisch definierten, xenofreien Mediums für die Co-Kultur von humanen adipogen differenzierten Stammzellen aus dem Fettgewebe und mikrovaskulären Endothelzellen

 

Simon Heine

M.Sc. Simon Heine

Thematische Schwerpunkte:

  • Co-culture systems
  • Cell-based test systems
  • Organ-on-a-chip
  • GC-MS analysis

Building 2
Room 008
Phone +49 07121 271-1496
Send e-mail »

Publications
  • Heine, Simon; Kleih, Markus; Giménez, Neus; Böpple, Kathrin; Ott, German; Colomer, Dolors et al. (2018): Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA. In: Journal of hematology & oncology 11 (1), S. 112. DOI: 10.1186/s13045-018-0657-6.
  • Höring, Elisabeth; Montraveta, Arnau; Heine, Simon; Kleih, Markus; Schaaf, Lea; Vöhringer, Matthias C. et al. (2017): Dual targeting of MCL1 and NOXA as effective strategy for treatment of mantle cell lymphoma. In: British journal of haematology 177 (4), S. 557–561. DOI: 10.1111/bjh.14571.
  • Schaaf, Lea; Schwab, Matthias; Ulmer, Christoph; Heine, Simon; Mürdter, Thomas E.; Schmid, Jens O. et al. (2016): Hyperthermia Synergizes with Chemotherapy by Inhibiting PARP1-Dependent DNA Replication Arrest. In: Cancer research 76 (10), S. 2868–2875. DOI: 10.1158/0008-5472.CAN-15-2908.
Vita

Since 06/2014

PhD student at the Margarete Fischer-Bosch Institute of Clinical Pharmacology Stuttgart and University of Tübingen
 “Role of aberrant Cyclin D1-CDK4 activity apart from cell cycle in Mantle Cell Lymphoma and consequences for novel treatment options”

09/2011 – 11/2014

Pharmaceutical Biotechnology (M. Sc.), University of Applied Sciences Jena
Master thesis: “Role of aberrant Cyclin D1-CDK4 activity apart from cell cycle in Mantle Cell Lymphoma and consequences for novel treatment options” at the Institute of Cell Biology and Immunology of the University of Stuttgart

03/2008 – 08/2011

Pharmaceutical Biotechnology (B. Sc.), University of Applied Sciences Biberach
Bachelor thesis: “Establishing a production process on the basis of HEK293 suspension cells” at U3 Pharma GmbH München

Projects

Forschungsprojekt:

MicroLungDetect

Corinna Jauch

M.Sc. Corinna Jauch

Thematische Schwerpunkte:

  • Sphäroide
  • Cultured Meat
  • Dynamische Kultur
  • Bioprinting

Building 2
Room 007
Phone +49 07121 271-1458
Send e-mail »

Vita

2020 – heute

Promotion: Biologie, Universität Hohenheim. Thema: Sphäroide als Grundbaustein für ein umweltfreundliches 'Cultured Meat' Produkt aus dem Biodruck (an der Hochschule Reutlingen)

2017 – 2020

Master: Technische Biologie, Universität Stuttgart. Thema: Interfacial characterization of with an isothiouronium surfmer functionalized poly(ethylene glycol) diacrylate hydrogels (Institut Institut für Grenzflächenverfahrenstechnik und Plasmatechnologie)

2014 – 2017

Bachelor: Technische Biologie, Universität Stuttgart. Thema: Characterization of the reaction of BRAF mutated melanoma to proteasome inhibition (Institut für Zellbiologie und Immunologie)

 

Projects

Projekt: 

Avina

    Lisa Michalek

    M.Sc. Lisa Michalek

    Thematische Schwerpunkte:

    • Extrusion-based Bioprinting
    • Tissue Engineering
    • Histology
    • Lab organization

    Building 2
    Room 009
    Phone +49 07121 271-8199
    Send e-mail »

    Vita
    Seit 03/2020

    Academic stuff member at Reutlingen Research Institute

    09/2016 – 07/2018:

    Biotechnology (M. Sc.), FH Aachen
    Master thesis: “Integration of electrospun membranes in microfluidic chip devices “at the Fraunhofer IGB, Stuttgart

    09/2012 – 08/2016:

    Biotechnology (B. Sc.), FH Aachen
    Bachelor thesis: “Evaluation and characterization of a novel PCL scaffold for cartilage tissue engineering “at the University Hospital Aachen

     

    Projects

    Projekte:

    • ImmuneFat2Skin
    • 6D-Biodruck
    Svenja Nellinger

    M.Sc. Svenja Nellinger

    Thematische Schwerpunkte:

    • Extrazelluläre Matrix
    • Zell-Material-Interaktion
    • Biomaterialien
    • Spektroskopische Zellcharakterisierung

    Building 2
    Room 011
    Phone +49 07121 271-1492
    Send e-mail »

    Publications

    Adipose stem cell-derived Extracellular Matrix represents a promising Biomaterial by inducing spontaneous formation of Prevascular-like Structures by MvECs
    Svenja Nellinger, Isabelle Schmidt, Simon Heine, Ann-Cathrin Volz and Petra J. Kluger
    Biotechnology and Bioengineering. 2020;1–13.
    DOI: 10.1002/bit.27481

    An Advanced “clickECM” that Can be Modified by the Inverse-Electron Demand Diels-Alder Reaction
    Svenja Nellinger, Mareike A. Rapp, Dr. Alexander Southan, Prof. Dr. Valentin Wittmann, Prof. Dr. Petra J. Kluger
    ChemBioChem. 2021
    https://doi.org/10.1002/cbic.202100266

    Generation of an azide-modified extracellular matrix by adipose-derived stem cells using metabolic glycoengineering
    Svenja Nellinger*, Silke Keller, Alexander Southan, Valentin Wittmann, Ann-Cathrin Volz and Petra J. Kluger
    Current Directions in Biomedical Engineering

    Cell-derived Extracellular Matrix as maintaining Biomaterial for adipogenic differentiation
    Svenja Nellinger, Simon Heine, Ann-Cathrin Volz and Petra J. Kluger*
    Current Directions in Biomedical Engineering
    https://doi.org/10.1515/cdbme-2020-3106

    Vita

    2016 – heute

    Promotion: Biologie, Universität Tübingen, Kooperatives Promotionskolleg Tübingen-Reutlingen, Thema: Hochdurchsatzerfassung von Zell-Material-Interaktion mittels Biomaterial Chip (an der Hochschule Reutlingen)

    2014 – 2016

    Master: Biologie (Schwerpunkt Physiologie), Universität Hohenheim, Thema: Completely defined adipogenic differentiation of adipose-derived stem cells and their validation as testing system (an der Hochschule Reutlingen)

    2010 – 2014

    Bachelor: Ernährungswissenschaften, Universität Hohenheim, Thema: Einfluss von Probiotika auf nicht-alkoholbedingte Fettlebererkrankungen

    Projects

    Projekt:

    ViaZell

    Sophia Nowakowski

    M.Sc. Sophia Nowakowski

    Thematische Schwerpunkte:

    • Haut Tissue Engineering
    • Zellkultur
    • Immunologie

    Building 2
    Room 007
    Phone +49 07121 271-1448
    Send e-mail »

    Publications

    Improvement of a three-layered in vitro skin model for topical application of irritating substances
    Freia Schmidt, Sophia Nowakowski, Petra J. Kluger
    Frontiers in Bioengineering and Biotechnology. 2020;1-11.
    doi: 10.3389/fbioe.2020.00388 

    Vita

    2021 – heute

    Promotion: 2021 – heute: Tissue Engineering, Universität Hohenheim, Thema: Ein humanes immunkompetentes 3-schichtiges Hautmodell als in vitro Testsystem (an der Hochschule Reutlingen)

    2019-2020:

    Industrie: Business Development Manager im Bereich Herz- und Lungenunterstützung, Medizintechnikunternehmen Heilbronn

    2017 – 2019

    Master: Biomedical Sciences, Hochschule Reutlingen, Thema: Improvement of a 3-layered in vitro skin model for topical application of irritating substances (an der Hochschule Reutlingen)

    2013 – 2017

    Bachelor: 2013 – 2017: Biomedizinische Wissenschaften, Hochschule Reutlingen, Thema: Establishment of an in vitro T cell receptor analysis system (am dkfz in Heidelberg)

     

    Projects

    Projekt:

    Immune-Fat2Skin

    Freia Schmidt

    M.Sc. Freia Schmidt

    Thematische Schwerpunkte:

    • Haut Tissue Engineering
    • Automatisierung im Tissue Engineering
    • Cokultur Systeme
    • Zellbasierte Testsysteme
    • Melanom

    Building 2
    Room 006
    Phone +49 07121 271-1441
    Send e-mail »

    Publications
    • Schmid FF*, Kleinhans C*, Schmid FV, Kluger PJ: Comparison of osteoclastogenesis and resorption activity of human osteoclasts on tissue culture polystyrene and on natural extracellular bone matrix in 2D and 3D; Journal of Biotechnology. 2015
    • Lotz C, Schmid FF, Rossi A, Kurdyn S, Kampik D, De Wever B, Walles H, Groeber FK:Alternative methods for the replacement of eye irritation testing; ALTEX. 2015
    • Schmid FF, Schwarz T, Klos M, Schuberthan W, Walles H, Hansmann J, and Groeber FK: Applicability of a Dual-Arm Robotic System for Automated Downstream Analysis of Epidermal Models. Applied In Vitro Toxicology. 2016
    • Groeber F, Engelhardt L, Lange J, Kurdyn S, Schmid FF, Rücker C, Mielke S, Walles H, Hansmann J:A first vascularized skin equivalent for as an alternative to animal experimentation; ALTEX. 2016
    • Groeber F, Schober L, Schmid FF, Traube A, Kolbus-Hernandez S, Daton K, Hoffmann S, Petersohn S, Schäfer-Korting M, Walles H., Mewes  :Catch-up validation study of an in vitro skin irritation test method based on an open source reconstructed epidermis (phase II), Toxicology in Vitro, Volume 36, 2016
    • Lotz C*, Schmid FF*, Oechsle E, Monaghan MG, Walles H, Groeber-Becker F: Cross-linked Collagen Hydrogel Matrix Resisting Contraction To Facilitate Full-Thickness Skin Equivalents, ACS Applied Materials & Interfaces, 2017
    • Rico Brendtke, Bart De Wever, Freia Schmid, Florian Groeber, Jan Hansmann, Heike Walles: High-Throughput Screening Techniques, in Alternatives for Dermal Toxicity Testing, C. Eskes, E. van Vliet, and H.I. Maibach, Editors. 2017, Springer International Publishing: Cham. p. 579-592.
    • Schmid FV, Kleinhans C, Schmid FF, Kluger PJ: Osteoclast Formation within a Human Co-Culture System on Bone Material as an In Vitro Model for Bone Remodeling Processes; JMFK, 2018
    • Schmid FF*, Grober-Becker F*, Schwab S, Thude S, Goebeler M, Walles H, Hansmann J: A standardized method based on pigmented epidermal models evaluates sensitivity against UV-irradiation; ALTEX, 2018
    • Lotz C., Kiesewetter L., Schmid FF., Hansmann J., Walles H., Groeber-Becker F: Replacing the Draize eye test: Impedance spectroscopy as a 3R method to discriminate between all GHS categories for eye irritation; Sci Rep, 2018
    • Schmidt, F.F., S. Nowakowski, and P.J. Kluger, Improvement of a Three Layered in vitro Skin Model for Topical Application of Irritating Substances Front, Bioeng Biotechnol , 2020

    *equally contributed

    Vita

    Seit 08/2018

    Reutlingen Research Institute

    01/2015 – 06/2018:

    Doktorandin an der Universität Würzburg betreut durch Prof. Dr. Heike Walles, Prof. Dr. Matthias Goebeler, Dr. Jan Hansmann und Dr. Florian Groeber-Becker 

    08/2017 – 06/2018

    Wissenschaftliche Mitarbeiterin, Fraunhofer ISC, Würzburg

    01/2013 – 08/2017

    Wissenschaftliche Mitarbeiterin, Translational Center Würzburg ‚Regenerative therapies in oncology and musculoskeletal disease, Zweigstelle des Fraunhofer IGB, Würzburg

    08/2013 – 12/2014

    Wissenschaftliche Mitarbeiterin, Fraunhofer IGB, Stuttgart

    09/2011 – 07/2013

    Biomedical Engineering (M. Sc.), Hochschule Albstadt-Sigmaringen

    Masterarbeit: “ Establishment of an osteoblast/osteoclast co-culture system to simulate the in vivo situation for testing iron-based bone replacement materials“ am Fraunhofer IGB, Abteilung CTE

    03/2007 – 09/2011

    Biotechnologie (B. Sc.), Hochschule Esslingen

    Bachelorarbeit: “ Investigation of modified titanium substrates for endo-exo prostheses in terms of their interaction with human skin cells“ am Fraunhofer IGB, Abteilung CTE

     

    Projects

    Projekte:

    • ImmuneFat2Skin
    • 6D Druck
    Jannis Wollschläger

    M.Sc. Jannis Wollschläger

    Thematische Schwerpunkte:

    • Cultured meat/ Cellular Agriculture
    • Tissue Engineering
    • 3D Bioprinting

    Building 2
    Room 008
    Phone +49 07121 271-1496
    Send e-mail »

    Vita

    Since 09/2019

    PhD student at the University of Hohenheim supervised by Prof. Dr. Petra Kluger and Prof. Dr. Melina Claussnitzer

    „Optimization of culture conditions for the defined differentiation, long-term and co-culture of adipose-derived stem cells for the setup of a fatty tissue model”

    04/2017 – 03/2019

    Industrial Biotechnology (M. Sc.), University of Applied Sciences Biberach/ Ulm University

    Master thesis: “Investigation of in-vitro test methods for release kinetics of bevacizumab and fluorescein isothiocyanate dextran from hydrogels or nanoparticles“ at the Institute for Applied Biotechnology of the University Biberach

    09/2013 – 03/2017

    Industrial Biotechnology (B. Sc.), University of Applied Sciences Biberach

    Bachelor thesis: “Investigation for solvent formations in Clostridium acetobutylicum“ at the Institute of Microbiology and Biotechnology of the University Ulm

    Projects